Job description

Acute myeloid leukemia (AML) is a type of hematological malignancies that is driven by many different transcription factors. Although the transcription factors are the key oncogenic drivers in AML, these proteins are difficult to be pharmacologically targeted. However, transcription factors always require many co-activators to control oncogenic transcriptional program. These co-activators are often druggable. Among these transcriptional co-activators, human BRG1/BRM associated factor (BAF) complexes play a critical role in many types of cancer including AML, and may also be the important therapeutic targets.

We are looking for a highly motivated research technician who is interested in studying molecular aspects of hematological malignancies. We will combine state-of-the-art gene editing, (epi)genomics, and computational methods to study the molecular functions of the BAF complexes in AML. Furthermore, we will test our anti-BAF therapies in 2D and 3D (primary) culture models. The ultimate goal of our research is to develop novel anti-AML therapeutics for AML treatment.

The initial employment will be one year, with a possible extension for 3 years after a positive evaluation.

Work environment

You will be part of a newly formed research group in the department of hematology at the Erasmus Medical Center in Rotterdam. Currently, the department has several research groups covering different topics of hematology, including basic and (pre-)clinical research in leukemia, myeloma, thrombosis and other blood related diseases. The new research team will focus on molecular aspect of human AML, and closely collaborate with other teams in the department to understand basic and translational questions of this disease.

Qualifications and skills

Requirements:

• You have a BSc/MSc in either (molecular) biology, genetics, or (bio)chemistry.
• Solid experience with molecular biology techniques, mammalian cell culture, and FACS analysis is a requirement;
• You are familiar with gene editing techniques such as CRISPR-CAS9.
• You are team-oriented, highly motivated, self-driven, and proficient in written and spoken English.

Desirable skills:

• You have experience in the relevant fields such as hematology or immunology.
• You are fimilar with epigenetic techniques such as ChIP-seq and ATAC-seq.
• You are familiar with human iPSC and/or organoids culture.

Before you apply please check our conditions for employment.

Terms of employment

• You will receive a temporary position for 1 year.
• The gross monthly salary amounts a minimum € 3.493,- and a maximum of € 5.504,- (scale 10).
• Excellent fringe benefits, such as a 13th month that is already paid out in November and a individual travel expense package.
• An International Office which aids you in preparing for you arrival and stay.
• Pension insurance with ABP. We take care of approximately 2/3 of the monthly contribution.
• Special benefits, such as a incompany physiotherapist and bicycle repairer. And there is also a gym where you can work on your fitness after work.

More information

For more information about this position, please contact Ningqing Liu, Assistant professor, via n.liu@erasmusmc.nl.

No agencies please.