Job description

Chronic infections with the hepatitis B virus (HBV) affect 250 million people worldwide, making it one of the most prevalent viral pathogens in men. These chronic infections are the major cause of liver cirrhosis and hepatocellular carcinoma. HBV is a non-cytopathic virus and HBV-related liver damage is caused by immune-mediated events during clearance of infected hepatocytes, and a role for virus-specific T cells has been firmly established. However, the involvement of B cells in controlling the HBV infection and in immunopathology of the liver is still elusive.

The aim of this study is to obtain insight into the role of B cells in HBV patients, through molecular characterization by immunological techniques, single cell RNASeq and B cell receptor sequencing of blood and liver virus-specific B cells of patients infected with HBV, and multiplex immunostainings. This project will lead to a better understanding of the role of B cells during chronic infection, which may guide improved treatment strategies aimed at therapeutic vaccines inducing antibody responses.

The research combines translational immunological studies on material from a large outpatient viral hepatitis cohort with clinical trials at the Erasmus MC in which novel antiviral compounds and treatment strategies are being evaluated.

Work environment

The laboratory of Gastroenterology and Hepatology of the Erasmus MC is a unique environment for high-level biomedical research on liver and gastrointestinal disease. The liver research of the laboratory focuses on chronic viral hepatitis, liver transplantation and hepatocellular carcinoma. The research group of Dr. Boonstra is an internationally acknowledged team of postdocs, PhD students, research physicians and technicians working in close interaction with the hepatologists of our clinic. More information about the research group can be found here.

Qualifications and skills

• You are a bright PhD student with a biomedical or life sciences degree.
• You have a strong interest in immunology of infectious diseases.
• Previous experience with immunological techniques and knowledge of R is an advantage.

Before you apply please check our conditions for employment.

Terms of employment

• You will receive a temporary position for 4 years.
• The gross monthly salary is € 3.017,- in the 1st year and increases to € 3.824,- in the 4th year (scale OIO).
• Excellent fringe benefits, such as a 13th month that is already paid out in November and an individual travel expense package.
• An International Office which aids you in preparing for you arrival and stay.
• Pension insurance with ABP, we take care of approximately 2/3 of the monthly contribution.
• Special benefits, such as an in-company physiotherapist and bicycle repairer. There is also a gym where you can work on your fitness after work.

More information

f you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.

For more information about this position, please contact Andre Boonstra, Experimental Hepatology Professor, p.a.boonstra@erasmusmc.nl.

No agencies please.